A memory chip capable of performing artificial intelligence operation and an operation method thereof are provided. The memory chip includes a memory array and an artificial intelligence engine. The memory array is configured to store input feature data and a plurality of weight data. The input feature data includes a plurality of first subsets, and each of the weight data includes a plurality of second subsets. The artificial intelligence engine includes a plurality of feature detectors. The artificial intelligence engine is configured to access the memory array to obtain the input feature data and the weight data. Each of the feature detectors selects at least one of the second subsets from the corresponding weight data as a selected subset based on a weight index, and the feature detectors perform a neural network operation based on the selected subsets and the corresponding first subsets.