Systems and methods to compensate for color fringe visual artifacts due at least in part to subpixel locations on an electronic display are provided. An electronic device may include subpixel layout compensation circuitry (SLCC) and an electronic display. The SLCC may receive first image data and an indication of spatial positions of subpixels that make up pixels of an electronic display. The SLCC may generate second image data based at least in part on the first image data and the indication of the spatial positions of the subpixels. The second image data may reduce or eliminate a color fringe artifact that would otherwise occur without compensation.