Invention Grant
- Patent Title: System for determining a copy number of a genomic sequence
-
Application No.: US14807764Application Date: 2015-07-23
-
Publication No.: US11238958B2Publication Date: 2022-02-01
- Inventor: Harrison Leong , Nivedita Sumi Majumdar
- Applicant: LIFE TECHNOLOGIES CORPORATION
- Applicant Address: US CA Carlsbad
- Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee: LIFE TECHNOLOGIES CORPORATION
- Current Assignee Address: US CA Carlsbad
- Agency: Mauriel Kapouytian Woods LLP
- Agent Liang Huang; Michael Mauriel
- Main IPC: G16B45/00
- IPC: G16B45/00 ; G16B20/00 ; G16B30/00 ; G16B20/20 ; G16B20/10

Abstract:
System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input.
Public/Granted literature
- US20160026760A1 Systems and Methods for the Determination of a Copy Number of a Genomic Sequence Public/Granted day:2016-01-28
Information query