Invention Grant
- Patent Title: Copper supplementation for control of glycosylation in mammalian cell culture process
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Application No.: US15519731Application Date: 2015-10-16
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Publication No.: US11268119B2Publication Date: 2022-03-08
- Inventor: Fernie Mitchelson , Erik Heller Hughes , Jessica Mondia , Robin Parish Hyde-Deruyscher
- Applicant: Biogen MA Inc.
- Applicant Address: US MA Cambridge
- Assignee: Biogen MA Inc.
- Current Assignee: Biogen MA Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2015/055856 WO 20151016
- International Announcement: WO2016/061424 WO 20160421
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N5/00 ; C07K16/28
Abstract:
The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Public/Granted literature
- US20170327861A1 Copper Supplementation for Control of Glycosylation in Mammalian Cell Culture Process Public/Granted day:2017-11-16
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