Disaggregated computing architectures, platforms, and systems are provided herein. In one example, a method of operating compute units is presented that includes forming compute units among a plurality of physical computing components coupled over a Peripheral Component Interconnect Express (PCIe) fabric configured to communicatively couple the plurality of physical computing components and isolate the compute unit using logical partitioning within the PCIe fabric. The method also includes initiating a software component deployed to at least associated CPUs within the compute units, reporting telemetry to the management processor related to operation of the compute unit, and emulating operation of at least one among an Ethernet and InfiniBand interface to an operating system of the associated CPU for transfer of communications comprising at least the telemetry to the management processor over the PCIe fabric.