Disaggregated computing architectures, platforms, and systems are provided herein. In one example, a method includes receiving user input to establish a compute unit comprising a host processor and at least two graphics processing units (GPUs) having a peer-to-peer capability. The method also includes instructing a management element for a communication fabric to form the compute unit and communicatively couple the host processor and the at least two GPUs over the communication fabric. The method also includes instructing the management element to establish an isolation function to form the peer arrangement between the at least two GPUs in the communication fabric, where the isolation function isolates a first address domain associated with the at least two GPUs from at least a second address domain associated with the host processor by at least establishing synthetic devices representing the at least two GPUs in the second address domain.