Invention Grant
- Patent Title: Compositions and methods of enhancing 5-hydroxytryptophan bioavailability
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Application No.: US15733423Application Date: 2019-01-28
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Publication No.: US11337963B2Publication Date: 2022-05-24
- Inventor: Jacob P. R. Jacobsen , Marc G. Caron
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Myers Bigel, P.A.
- International Application: PCT/US2019/015391 WO 20190128
- International Announcement: WO2019/148087 WO 20190801
- Main IPC: A61K31/405
- IPC: A61K31/405 ; A61K31/135 ; A61K31/138 ; A61K31/15 ; A61K31/198 ; A61K31/343 ; A61K31/4406 ; A61K31/4525 ; A61K31/454 ; A61K31/495 ; A61K31/496
Abstract:
Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s).
Public/Granted literature
- US20210346345A1 COMPOSITIONS AND METHODS OF ENHANCING 5-HYDROXYTRYPTOPHAN BIOAVAILABILITY Public/Granted day:2021-11-11
Information query
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