Methods, apparatus, systems and articles of manufacture to recommend instruction adaptations to improve compute performance are disclosed. An example apparatus includes a pattern detector to detect an execution pattern from an execution profile provided by a server, the execution profile associated with an instruction stored in an instruction repository. An adaptation identifier is to identify a possible instruction adaptation that may be applied to the instruction associated with the execution pattern. A model processor is to predict, using a machine learning model, an expected performance improvement of the adaptation. A result comparator is to determine whether the expected performance improvement meets an threshold. An instruction editor is to, in response to the result comparator determining that the expected performance improvement meets the threshold, apply the possible instruction adaptation to the instruction in the instruction repository.