Invention Grant
- Patent Title: Metal complexes with bisphophonate or pyrophosphate useful as imaging agents
-
Application No.: US16373803Application Date: 2019-04-03
-
Publication No.: US11351275B2Publication Date: 2022-06-07
- Inventor: Christopher David Lascola
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Myers Bigel, P.A.
- Main IPC: A61B5/055
- IPC: A61B5/055 ; A61K49/10 ; A61K49/08 ; A61K47/54 ; A61P35/00 ; A61K9/00 ; A61K31/663 ; A61K31/675 ; A61K49/06
Abstract:
Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.
Public/Granted literature
- US20190231907A1 Metal Complexes with Bisphophonate or Pyrophosphate Useful as Imaging Agents Public/Granted day:2019-08-01
Information query
