- Patent Title: Genome engineering with type I CRISPR systems in eukaryotic cells
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Application No.: US16837395Application Date: 2020-04-01
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Publication No.: US11421251B2Publication Date: 2022-08-23
- Inventor: Charles A. Gersbach , Adrian Pickar Oliver , Chase Beisel
- Applicant: Duke University , North Carolina State University
- Applicant Address: US NC Durham; US NC Raleigh
- Assignee: Duke University,North Carolina State University
- Current Assignee: Duke University,North Carolina State University
- Current Assignee Address: US NC Durham; US NC Raleigh
- Agency: Michael Best & Friedrich LLP
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N9/22 ; C12N15/10 ; C12N15/11
Abstract:
Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.
Public/Granted literature
- US20200318139A1 GENOME ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS Public/Granted day:2020-10-08
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