A power switch circuit is disclosed. The power switch circuit includes an input terminal, an output terminal, a first switch, a second switch, a sensing switch and an adjusting circuit. The first switch is coupled to the input terminal. The second switch is coupled to the first switch and the output terminal. A first node between the first switch and the second switch has a first node voltage. A breakdown voltage of the second switch is higher than that of the first switch. The sensing switch is coupled to the input terminal and the first switch. The adjusting circuit is coupled to the first node and the sensing switch. A second node between the adjusting circuit and the sensing switch has a second node voltage. The adjusting circuit adjusts the second node voltage according to the first node voltage to make it equal to the first node voltage.