The subject matter described herein includes methods, systems, and computer readable media for mask embedding for realistic high-resolution image synthesis. According to one method for mask embedding for realistic high-resolution image synthesis includes receiving, as input, a mask embedding vector and a latent features vector, wherein the mask embedding vector acts as a semantic constraint; generating, using a trained image synthesis algorithm and the input, a realistic image, wherein the realistic image is constrained by the mask embedding vector; and outputting, by the trained image synthesis algorithm, the realistic image to a display or a storage device.