Methods, apparatus, and systems to replace values in a device are disclosed. An example apparatus includes a processor and a replacement generator coupled to the processor and configured to detect an access, by the processor, of a first instruction at a first address in a first memory, in response to the detected access, compare the first address to a set of trigger instruction address records in a second memory, wherein the set of trigger instruction address records includes a first trigger instruction address record that is associated with a first replacement address record and a first replacement value record, and based on the first address corresponding to the first trigger instruction address record, replace a first value at a second address in a third memory specified by the first replacement address record with a second value specified by the first replacement value record.