An electrostatic discharge protection circuit, including a discharge switch, a first transistor, an inverter, and a feedback circuit, is provided. The discharge switch is coupled between a first power rail and a second power rail, and may be turned on or cut off according to a control voltage. The first transistor has a first end coupled to the first power rail. A control end of the first transistor receives the control voltage. The inverter is coupled between a second end of the first transistor and a control end of the discharge switch. The feedback circuit is coupled between an output end and an input end of the inverter and is configured to determine whether to provide a turn-on path between the input end of the inverter and the second power rail according to the control voltage.