Invention Grant
- Patent Title: Conditional-siRNAS and uses thereof in treating acute myeloid leukemia
-
Application No.: US16786793Application Date: 2020-02-10
-
Publication No.: US11643659B2Publication Date: 2023-05-09
- Inventor: Guido Marcucci , Ya-Huei Kuo , Si-ping Han , Lisa Scherer , William A. Goddard, III , John Rossi
- Applicant: CITY OF HOPE , CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Duarte
- Assignee: CITY OF HOPE,CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CITY OF HOPE,CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Duarte; US CA Pasadena
- Agency: Perkins Coie LLP
- Agent Lara J. Dueppen
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
Disclosed herein are conditional siRNAs activatable by CBFβ-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.
Public/Granted literature
- US20210123060A1 CONDITIONAL-siRNAS AND USES THEREOF IN TREATING ACUTE MYELOID LEUKEMIA Public/Granted day:2021-04-29
Information query
IPC分类:
