Invention Grant
- Patent Title: Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
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Application No.: US16477229Application Date: 2018-01-12
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Publication No.: US11648200B2Publication Date: 2023-05-16
- Inventor: Ashutosh Chilkoti , Davoud Mozhdehi , Kelli M. Luginbuhl
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2018/013611 2018.01.12
- International Announcement: WO2018/132732A 2018.07.19
- Date entered country: 2019-07-11
- Main IPC: A61K47/42
- IPC: A61K47/42 ; C07K14/78 ; A61K38/00 ; A61K9/107 ; C12N1/20 ; C12N9/10 ; C12P21/00
Abstract:
Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide, where the conjugates have phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.
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