Invention Grant
- Patent Title: Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
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Application No.: US16321695Application Date: 2017-07-31
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Publication No.: US11712480B2Publication Date: 2023-08-01
- Inventor: Russell George Dushin , Daniel P. Uccello , Jeremy Starr , Ye Che , Mark Flanagan , Jeffrey M. Casavant , Christopher John O'Donnell , Gary Frederick Filzen , Jennifer Young , Joseph A. Abramite , Lawrence N. Tumey , Ludivine Moine , Adam Matthew Gilbert , Lee R. Roberts
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agency: Saul Ewing LLP
- Agent Domingos J. Silva
- International Application: PCT/IB2017/054675 2017.07.31
- International Announcement: WO2018/025168A 2018.02.08
- Date entered country: 2019-01-29
- Main IPC: A61K47/54
- IPC: A61K47/54 ; A61K47/68 ; C07K4/00 ; C07K5/02 ; C07K7/02 ; A61K47/50 ; C07K5/062
Abstract:
The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:
(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.
(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.
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