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Patent Agency Ranking
公开(公告)号：US11712480B2
公开(公告)日：2023-08-01
申请号：US16321695
申请日：2017-07-31
Applicant: PFIZER INC.
Inventor： Russell George Dushin , Daniel P. Uccello , Jeremy Starr , Ye Che , Mark Flanagan , Jeffrey M. Casavant , Christopher John O'Donnell , Gary Frederick Filzen , Jennifer Young , Joseph A. Abramite , Lawrence N. Tumey , Ludivine Moine , Adam Matthew Gilbert , Lee R. Roberts
CPC classification number: A61K47/6855 , A61K47/50 , A61K47/545 , A61K47/6867 , C07K4/00 , C07K5/0205 , C07K5/06052 , C07K7/02
Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:
(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.-
公开(公告)号：US20240409573A1
公开(公告)日：2024-12-12
申请号：US18627949
申请日：2024-04-05
Applicant: PFIZER INC.
Inventor： Omar Khaled Ahmad , Stephen Paul Brown , Kenneth John Dirico , Russell Dushin , Gary Frederick Filzen , Sujiet Puthenveetil , Pavel Strop , Chakrapani Subramanyam , Lawrence N. Tumey
Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
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公开(公告)号：US11993625B2
公开(公告)日：2024-05-28
申请号：US16477290
申请日：2018-01-10
Applicant: PFIZER INC.
Inventor： Omar Khaled Ahmad , Stephen Paul Brown , Kenneth John Dirico , Russell Dushin , Gary Frederick Filzen , Sujiet Puthenveetil , Pavel Strop , Chakrapani Subramanyam , Lawrence N. Tumey
CPC classification number: C07H15/26 , A61K47/6807 , A61P35/00 , A61K45/06
Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.
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公开(公告)号：US11365263B2
公开(公告)日：2022-06-21
申请号：US17091097
申请日：2020-11-06
Applicant: PFIZER INC.
Inventor： Andreas Maderna , Chakrapani Subramanyam , Lawrence N. Tumey , Zecheng Chen , Jeffrey M. Casavant
IPC: C07K16/32 , C07D519/00 , C07F9/6561 , C07K5/062 , C07K5/09 , C07B59/00 , C07K16/28 , C07D495/04 , A61K47/68 , A61K47/65
Abstract: The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs; and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.
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公开(公告)号：US10723727B2
公开(公告)日：2020-07-28
申请号：US16072291
申请日：2017-01-27
Applicant: PFIZER INC. , CovX Technologies Ireland Limited
Inventor： Chakrapani Subramanyam , Lawrence N. Tumey , Longfei Xie , Carolyn Leverett , Beth C. Vetelino , Sai Chetan K. Sukuru , Sarah Hudson , Venkata Ramana Doppalapudi , Abhijit S. Bhat
IPC: A61K31/426 , A61K31/427 , A61K31/4025 , A61K47/65 , C07D277/56 , C07D417/12 , A61P35/00 , C07D277/42 , A61K47/68
Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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