A method of controlling a propulsion system inverter includes identifying at least one route characteristic of a portion of a route being traversed by a vehicle. The method further includes Receiving at least one inverter characteristic. The method further includes generating a target thermal profile of the propulsion system inverter corresponding to thermal fatigue associated with the at least one thermal characteristic. The method further includes generating a signal to selectively instruct the adjustment of at least one of the vehicle speed control input, a torque demand corresponding to the vehicle speed control input, and the portion of the route based on the target thermal profile of the propulsion system inverter to improve inverter life.