Multi-mode capacitive micromachined ultrasound transducer (CMUT) and associated devices systems, and methods are provided. In an embodiment, an intravascular device includes a flexible elongate member having a proximal portion, a distal portion, and a first sensor assembly disposed at the distal portion of the flexible elongate member. The first sensor assembly comprising comprises a first array of capacitive micromachined ultrasonic transducers (CMUTs). The first sensor assembly comprises at least two of a pressure sensor, a flow sensor, or an imaging sensor. In some embodiments, the intravascular device further includes a second sensor assembly comprising a second array of CMUTs.