Systems and methods related to a cryogenic-CMOS interface for controlling qubit gates are provided. A system for controlling qubit gates includes a first device comprising a quantum device including qubit gates. The system further includes a second device comprising a control system configured to operate at the cryogenic temperature. The control system includes charge locking circuits, where each of the charge locking circuits is coupled to at least one qubit gate via an interconnect such that each of the charge locking circuits is configured to provide a voltage signal to at least one qubit gate. The control system further includes a control circuit comprising a finite state machine configured to provide at least one control signal to selectively enable at least one of the charge locking circuits and to selectively enable a provision of a voltage signal to a selected one of the charge locking circuit.