Invention Grant
- Patent Title: Quinone-containing conjugates
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Application No.: US16523384Application Date: 2019-07-26
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Publication No.: US11857638B2Publication Date: 2024-01-02
- Inventor: Wenhui Zhou , Hui Wang , James J. Cali , Sarah Duellman , Jolanta Vidugiriene , Natasha Karassina
- Applicant: PROMEGA CORPORATION
- Applicant Address: US WI Madison
- Assignee: PROMEGA CORPORATION
- Current Assignee: PROMEGA CORPORATION
- Current Assignee Address: US WI Madison
- Agency: Casimir Jones, S.C.
- Agent Anne M. Reynolds
- Main IPC: A61K31/122
- IPC: A61K31/122 ; C07D417/12 ; C07K16/30 ; A61P35/00 ; A61K47/68 ; G01N33/58 ; A61K49/00
Abstract:
Conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. The quinone-containing linker may be reduced intracellularly to trigger release of the drug or probe. These conjugates may selectively deliver a drug or probe to a site of action of interest for local release of the active drug or probe.
Public/Granted literature
- US20200030456A1 QUINONE-CONTAINING CONJUGATES Public/Granted day:2020-01-30
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