Systems and methods are disclosed for magnetoresistive asymmetry compensation using a hybrid analog and digital compensation scheme. In certain embodiments, a method may comprise receiving an analog signal at a continuous-time front end (CTFE) circuit, and performing, via the CTFE circuit, first magnetoresistive asymmetry (MRA) compensation on the analog signal to adjust the dynamic range of the analog signal based on an input range of an analog-to-digital converter (ADC). The method may further comprise converting the analog signal to a digital sample sequence via the ADC, and performing, via a digital MRA compensation circuit, second MRA compensation to correct residual MRA in the digital sample sequence. Offset compensation may also be performed in both the analog and digital domains.