Communication fabric-coupled computing architectures, platforms, and systems are provided herein. In one example, an apparatus includes a management entity configured to establish a compute unit comprising components from among a plurality of physical computing components by at least instructing a communication fabric communicatively coupling the plurality of physical computing components to establish logical isolation within the communication fabric to form the compute unit. Responsive to an indication of a change in workload associated with at least a software component deployed to a processing element of the compute unit, the management entity is configured to adjust the logical isolation to alter a quantity of the plurality of physical computing components in the compute unit in accordance with the change in the workload.