Disaggregated computing architectures, platforms, and systems are provided herein. In one example, a method includes instructing a communication fabric to establish a first logical partition in the communication fabric that includes a first processing device and a memory device, and directing transfer of configuration data for storage by the memory device over the first logical partition. After transfer of the configuration data, the method includes instructing the communication fabric to remove the first logical partition in the communication fabric, where the configuration data remains stored by the memory device after removal of the first logical partition. The method also includes instructing the communication fabric to establish a second logical partition in the communication fabric that includes at least a second processing device and the memory device comprising the configuration data, where the second processing device is operated using the configuration data.