A method for producing an electrocompacted and aligned strand is disclosed. The method includes the steps of: providing a channel having an anode on one side and a cathode on the other side separated by a non-conductive material to form an electrode; dispensing a solution comprising one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature into the channel to complete a circuit between the anode and the cathode; applying a DC current in the range of 1-200 volts to the electrode through the solution in the channel to form an electrocompacted and aligned strand; and transferring the aligned strand out of the electrode. The one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature can comprise collagen molecules that have different charges at different pH values. Materials including electrochemically aligned and compacted compounds are also disclosed.