This automated travel system for spraying work has a target path generation unit for generating a target path for a spraying work. A work vehicle is provided with left and right liquid spraying units which have spraying patterns including: a four-direction spraying pattern in which each of the left and right liquid spraying units sprays a liquid to both the left and right directions; and a direction-restricted spraying pattern in which the number of spraying directions of the left and right liquid spraying units is restricted to 3 or less. The target path generation unit generates the target path P in a path setting to incorporate a four-direction spraying path for which the four-direction spraying pattern is set as a spraying pattern and direction-restricted spraying paths for which the direction-restricted spraying pattern is set as a spraying pattern.