A power converter having a multi-stage high-side driving mechanism is provided. A control circuit outputs a first high-side control signal. A high-side driving circuit, according to the first high-side control signal and a first input voltage signal, outputs a first stage high-side driving signal to a control terminal of a high-side switch. As a result, a voltage of the control terminal of the high-side switch is pulled up to a first stage voltage from zero. Then, the control circuit outputs a second high-side control signal. A charge pump outputs a charging signal. The high-side driving circuit, according to the second high-side control signal and the charging signal, outputs a second stage high-side driving signal to the control terminal of the high-side switch. As a result, the voltage of the control terminal of the high-side switch is pulled up from the first stage voltage to a target voltage.