Examples described herein relate to network layer 7 (L7) offload to an infrastructure processing unit (IPU) for a service mesh. An apparatus described herein includes an IPU comprising an IPU memory to store a routing table for a service mesh, the routing table to map shared memory address spaces of the IPU and a host device executing one or more microservices, wherein the service mesh provides an infrastructure layer for the one or more microservices executing on the host device; and one or more IPU cores communicably coupled to the IPU memory, the one or more IPU cores to: host a network L7 proxy endpoint for the service mesh, and communicate messages between the network L7 proxy endpoint and an L7 interface device of the one or more microservices by copying data between the shared memory address spaces of the IPU and the host device based on the routing table.