Disclosed are a bus inversion encoder module that utilizes future data in a data bus including a serializer with minimum latency and high transition reduction efficiency by comparing current data with both past data and the future data and encoding the current data, and a bus inversion system including the same. The bus inversion encoder module uses current data, past data, and future data transmitted through a bus and each including a plurality of bits, determines whether to invert the current data, and generates a current flag and coded current data by using whether to invert, an output flag, and the current data. The output flag is generated by summing the current flag and the coded current data and serially converting the current flag and the coded current data.