Invention Application
US20120301895A1 METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING
审中-公开
调节方法将无盐酸溶解于磷酸和鉴定化合物的方法进行调节这种结合
- Patent Title: METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING
- Patent Title (中): 调节方法将无盐酸溶解于磷酸和鉴定化合物的方法进行调节这种结合
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Application No.: US13568878Application Date: 2012-08-07
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Publication No.: US20120301895A1Publication Date: 2012-11-29
- Inventor: Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
- Applicant: Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
- Applicant Address: US NY Stony Brook US NY New York
- Assignee: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK,NEW YORK UNIVERSITY
- Current Assignee: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK,NEW YORK UNIVERSITY
- Current Assignee Address: US NY Stony Brook US NY New York
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras.
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