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公开(公告)号：US20120288862A1
公开(公告)日：2012-11-15
申请号：US13520176
申请日：2010-12-29
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
Abstract: The present invention relates to an assay kit for quantitatively detecting k-ras gene mutations. Particularly, the present invention relates to detection method and a detection kit for K-ras gene mutations, which relates to the therapeutic efficacy of targeted molecular anti-cancer drugs. More particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of K-ras gene, together with the use thereof. The present invention detects the mutations at specific sites of K-ras gene, and can predict the therapeutic efficacy of anti-EGFR tyrosine kinase inhibitors. Therefore, it can provide a guidance to individualized treatments for cancer patients.
Abstract translation: 本发明涉及用于定量检测k-ras基因突变的测定试剂盒。 特别地，本发明涉及K-ras基因突变的检测方法和检测试剂盒，涉及靶向分子抗癌药物的治疗功效。 更具体地，本发明涉及用于检测K-ras基因的热点的突变的荧光定量PCR方法和试剂盒及其用途。 本发明检测K-ras基因特异位点的突变，可预测抗EGFR酪氨酸激酶抑制剂的治疗效果。 因此，可为癌症患者的个体化治疗提供指导。
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公开(公告)号：US20120232239A1
公开(公告)日：2012-09-13
申请号：US13415470
申请日：2012-03-08
Applicant: Guillermo C. Bazan , Lei YING , Zhao CHEN , Thuc-Quyen NGUYEN
Inventor： Guillermo C. Bazan , Lei YING , Zhao CHEN , Thuc-Quyen NGUYEN
IPC: C08G79/08
CPC classification number: C08G79/08 , C08G61/02 , C08G2261/126 , C08G2261/143 , C08G2261/146 , C08G2261/3142 , C08G2261/411 , C08G2261/414 , C08G2261/91 , C08G2261/92 , C08G2261/94 , C08G2261/95 , H01L51/0039 , H01L51/5072
Abstract: A method for the production neutral triblock all-conjugated copolymers by palladium-catalyzed chain-growth polymerization, and methods to convert these copolymers into all-conjugated triblock polyelectrolytes with well-controlled molecular weight and polydispersity. A device is provided which incorporates such all-conjugated triblock polyelectrolytes as an electron injection layer.
Abstract translation: 通过钯催化的链增长聚合制备中性三嵌段全共轭共聚物的方法，以及将这些共聚物转变为具有良好控制的分子量和多分散性的全共轭三嵌段聚电解质的方法。 提供了一种装配有这样的全共轭三嵌段聚电解质作为电子注入层的装置。
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3.发明申请PLASMID STANDARD FOR USE IN QUANTITATIVE ASSAYS USING FLUORESCENT QUANTITATIVE PCR 审中-公开使用荧光定量PCR定量测定中的PLASMID标准公开(公告)号：US20130217115A1
公开(公告)日：2013-08-22
申请号：US13880373
申请日：2011-10-18
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6851 , C12Q2545/101
Abstract: Disclosed is a plasmid standard for use in fluorescent quantitative PCR assays. More specifically, the present invention provides a plasmid standard as well as amplification primers and detection probes thereof for use in the detection of gene mutation and expression amount.
Abstract translation: 公开了用于荧光定量PCR测定的质粒标准品。 更具体地，本发明提供了用于检测基因突变和表达量的质粒标准品以及扩增引物及其检测探针。
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4.发明申请METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING 审中-公开调节方法将无盐酸溶解于磷酸和鉴定化合物的方法进行调节这种结合公开(公告)号：US20120301895A1
公开(公告)日：2012-11-29
申请号：US13568878
申请日：2012-08-07
Applicant: Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
Inventor： Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
IPC: G01N33/53
CPC classification number: G01N33/5011 , G01N2333/4706 , G01N2333/916
Abstract: The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras.
Abstract translation: 本发明涉及调节7位儿子与磷脂酸结合的方法，并鉴定调节这种结合的化合物。 特别地，本发明涉及一种控制七分之一或七分之一子宫不育或组蛋白折叠域依赖性膜募集的睡眠蛋白同源结构域依赖性膜募集的方法。 还公开了控制Ras并治疗受试者由Ras介导的病症的方法。 本发明还涉及鉴定潜在有效治疗由Ras介导的病症的化合物的方法。
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5.发明申请REAGENT KIT FOR QUANTITATIVELY DETECTING THE MUTATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR(EGFR) 审中-公开定量检测天然生长因子受体（EGFR）突变的试剂盒公开(公告)号：US20120237935A1
公开(公告)日：2012-09-20
申请号：US13497527
申请日：2010-09-20
CPC classification number: C12Q1/6886 , C12Q1/6851 , C12Q2600/156
Abstract: The present invention relates to a detection method and a detection kit for EGFR gene mutations, which relates to the therapeutic efficacy of molecular-targeted anti-cancer drugs. Particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of EGFR gene, together with the use thereof. The present invention detects the mutations at specific sites of EGFR gene, and can predict the therapeutic efficacy of EGFR tyrosine kinase inhibitors. Therefore, it can provide a guidance to individualize treatments for cancer patients.
Abstract translation: 本发明涉及EGFR基因突变的检测方法和检测试剂盒，其涉及分子靶向抗癌药物的治疗功效。 特别地，本发明涉及用于检测EGFR基因热点突变的荧光定量PCR方法及试剂盒及其应用。 本发明检测EGFR基因特异位点的突变，可预测EGFR酪氨酸激酶抑制剂的治疗效果。 因此，可以为个体化癌症患者的治疗提供指导。
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Patent Agency Ranking
6.发明申请METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING 审中-公开调节方法将无盐酸溶解于磷酸和鉴定化合物的方法进行调节这种结合公开(公告)号：US20090137654A1
公开(公告)日：2009-05-28
申请号：US12114914
申请日：2008-05-05
Applicant: Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
Inventor： Dafna BAR-SAGI , Zhao CHEN , Karl SKOWRONEK , Kamlesh K. YADAV
IPC: A61K31/4164 , C12N5/06 , A61K31/195 , C12Q1/44 , G01N33/566 , C12N9/99
CPC classification number: G01N33/5011 , G01N2333/4706 , G01N2333/916
Abstract: The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras.
Abstract translation: 本发明涉及调节7位儿子与磷脂酸结合的方法，并鉴定调节这种结合的化合物。 特别地，本发明涉及一种控制七分之一或七分之一子宫不育或组蛋白折叠域依赖性膜募集的睡眠蛋白同源结构域依赖性膜募集的方法。 还公开了控制Ras并治疗受试者由Ras介导的病症的方法。 本发明还涉及鉴定潜在有效治疗由Ras介导的病症的化合物的方法。
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公开(公告)号：US5962197A
公开(公告)日：1999-10-05
申请号：US49294
申请日：1998-03-27
Applicant: Zhao Chen
Inventor： Zhao Chen
IPC: C11D3/02 , C11D3/20 , C11D3/28 , C11D3/30 , C11D11/00 , G03F7/42 , H01L21/311 , G03C5/00 , B08B7/00
CPC classification number: C11D3/044 , C11D11/0047 , C11D3/2068 , C11D3/28 , C11D3/30 , G03F7/425 , H01L21/31133
Abstract: A stripper for removing photoresist or solder masks has a composition of 30-80% by weight of a propylene glycol ether; 10-60% by weight of a pyrrolidone; 0.1-5% by weight of potassium hydroxide; 0.1-10% by weight of a surfactant; 0-20% by weight 1,3-butanediol; 0-10% by weight 2-(2-aminoethoxy) ethanol; and a water content of
Abstract translation: 用于除去光致抗蚀剂或焊接掩模的剥离器具有30-80重量％的丙二醇醚的组成; 10-60重量％的吡咯烷酮; 0.1-5重量％的氢氧化钾; 0.1-10重量％的表面活性剂; 0-20重量％1,3-丁二醇; 0-10重量％2-（2-氨基乙氧基）乙醇; 含水量<1％。
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公开(公告)号：US08779077B2
公开(公告)日：2014-07-15
申请号：US13415470
申请日：2012-03-08
Applicant: Guillermo C. Bazan , Lei Ying , Zhao Chen , Thuc-Quyen Nguyen
Inventor： Guillermo C. Bazan , Lei Ying , Zhao Chen , Thuc-Quyen Nguyen
IPC: C08G79/08
CPC classification number: C08G79/08 , C08G61/02 , C08G2261/126 , C08G2261/143 , C08G2261/146 , C08G2261/3142 , C08G2261/411 , C08G2261/414 , C08G2261/91 , C08G2261/92 , C08G2261/94 , C08G2261/95 , H01L51/0039 , H01L51/5072
Abstract: A method for the production neutral triblock all-conjugated copolymers by palladium-catalyzed chain-growth polymerization, and methods to convert these copolymers into all-conjugated triblock polyelectrolytes with well-controlled molecular weight and polydispersity. A device is provided which incorporates such all-conjugated triblock polyelectrolytes as an electron injection layer.
Abstract translation: 通过钯催化的链增长聚合制备中性三嵌段全共轭共聚物的方法，以及将这些共聚物转变为具有良好控制的分子量和多分散性的全共轭三嵌段聚电解质的方法。 提供了一种装配有这样的全共轭三嵌段聚电解质作为电子注入层的装置。
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公开(公告)号：US20130095491A1
公开(公告)日：2013-04-18
申请号：US13581008
申请日：2011-02-22
CPC classification number: C12Q1/6886 , C12Q1/686 , C12Q2600/106 , G01N2021/6432
Abstract: The present invention relates to a method and assay kit for BRAF gene mutations which relates to the effect of molecule-targeting anti-tumor drug. Particularly, the present invention relates to a fluorescent quantitative PCR method and kit for detecting mutations at hotspots of BRAF gene, together with the use thereof. The present invention detects the mutations at specific sites of BRAF gene, and can predict the therapeutic efficacy of anti-EGFR tyrosine kinase inhibitors, an anti-tumor drug. Therefore, the present invention can provide a guidance to individualized treatments for cancer patients.
Abstract translation: 本发明涉及涉及分子靶向抗肿瘤药物的作用的BRAF基因突变的方法和测定试剂盒。 特别地，本发明涉及用于检测BRAF基因热点突变的荧光定量PCR方法及试剂盒及其用途。 本发明检测BRAF基因特异位点的突变，可以预测抗EGFR酪氨酸激酶抑制剂抗肿瘤药物的疗效。 因此，本发明可以为癌症患者的个体化治疗提供指导。
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公开(公告)号：US10385404B2
公开(公告)日：2019-08-20
申请号：US15314952
申请日：2015-05-27
IPC: C07H21/02 , C07H21/04 , C12Q1/6886 , C12Q1/68 , C12Q1/6848 , C12Q1/6858
Abstract: This invention relates to a kit for detecting NRAS gene mutation, and this kit can be used to detect cancer-related NRAS gene mutation. The said kit comprises: (1) the internal reference detection reagent, which includes the internal reference gene specific primers, internal reference gene specific probes and dNTP solution; (2) the NRAS mutation detection reagent, which includes the NRAS gene mutant type specific primers, NRAS gene mutant type specific probes, internal control gene specific primers, internal control gene specific probes and dNTP solution; (3) the Taq DNA polymerase; and (4) the NRAS positive quality control.
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