The present invention discloses a mobile health intelligent medical guide system and method thereof. The method comprises steps: collecting patient chief complaint, sending the patient chief complaint to a cloud server, analyzing and processing the patient chief complaint, text word segmentation, fuzzy matching and sorting recommendation technologies, generating a disease examination result, and generating an intelligent medical guide result to be fed back to the mobile terminal; reminding the patient to supplement the chief complaint information if the patient does not end this query or the diagnosis result does not achieve the optimum, and then optimizing the disease examination result and the intelligent medical guide result until the patient ends the query or the diagnosis result achieves the optimum. The system disclosed can assist the patient to perform self-helped disease examination and medical guide in the mobile environment, thereby promoting the development of the mobile medical technology.