A caulk cartridge for use with high organic solvent caulk is disclosed. The cartridge includes a cartridge body formed as an open-ended elongate cylindrical tube having a first end, a second end, and an inner surface, a nozzle affixed to the first end of the cartridge body, and a plunger engaging with the inner surface of the cartridge body and forming a seal at the second end and slidable along a longitudinal axis of the cartridge body from the second end toward the first end. The cartridge body is manufactured from a cellulosic thermoplastic with a high organic solvent barrier.