Invention Publication
- Patent Title: PURIFICATION OF ANTIBODY DRUG CONJUGATES USING A SODIUM PHOSPHATE GRADIENT
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Application No.: US18322395Application Date: 2023-05-23
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Publication No.: US20240150394A1Publication Date: 2024-05-09
- Inventor: Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: PFIZER INC.
- Current Assignee: PFIZER INC.
- Current Assignee Address: US NY New York
- Main IPC: C07K1/18
- IPC: C07K1/18 ; A61K47/68
Abstract:
Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
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