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公开(公告)号：US20240150394A1
公开(公告)日：2024-05-09
申请号：US18322395
申请日：2023-05-23
Applicant: PFIZER INC.
Inventor： Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang
CPC classification number: C07K1/18 , A61K47/6811 , A61K47/6849
Abstract: Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
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公开(公告)号：US11661438B2
公开(公告)日：2023-05-30
申请号：US15778290
申请日：2016-12-07
Applicant: PFIZER INC.
Inventor： Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang
CPC classification number: C07K1/18 , A61K47/6811 , A61K47/6849
Abstract: Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
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