Invention Grant
- Patent Title: Method of phosphate ester hydrolysis
- Patent Title (中): 磷酸酯水解方法
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Application No.: US486962Application Date: 1995-06-07
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Publication No.: US5763172APublication Date: 1998-06-09
- Inventor: Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
- Applicant: Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
- Applicant Address: TX Austin CA Sunnyvale
- Assignee: Board of Regents, The University of Texas System,Pharmacyclics, Inc.
- Current Assignee: Board of Regents, The University of Texas System,Pharmacyclics, Inc.
- Current Assignee Address: TX Austin CA Sunnyvale
- Main IPC: A61K41/00
- IPC: A61K41/00 ; A61K47/48 ; A61K49/00 ; B01J31/06 ; B01J31/16 ; B01J31/18 ; C07D487/22 ; C07H21/00 ; C12Q1/68 ; A01N61/00 ; C07H19/00
Abstract:
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.
Public/Granted literature
- US5000851A Turbine filter with pressure seal bonnet Public/Granted day:1991-03-19
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