公开(公告)号：US5763172A

公开(公告)日：1998-06-09

申请号：US486962

申请日：1995-06-07

Applicant: Darren Magda ,  Jonathan L. Sessler ,  Meredith Wright ,  Richard A. Miller ,  William C. Dow

Inventor： Darren Magda ,  Jonathan L. Sessler ,  Meredith Wright ,  Richard A. Miller ,  William C. Dow

IPC: A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C12Q1/68 ,  A01N61/00 ,  C07H19/00

CPC classification number: A61K47/48069 ,  A61K41/0038 ,  A61K49/0021 ,  A61K49/0054 ,  B01J31/1658 ,  B01J31/1815 ,  C07D487/22 ,  C07H21/00 ,  B01J2531/025 ,  B01J2531/38 ,  B01J31/061

Abstract: A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.

Abstract translation: 一种磷酸酯水解方法，包括在足以水解磷酸酯的条件和时间下孵育磷酸酯水溶液与金属脱甲苯吡啶络合物的溶液。 金属是在水溶液中具有酯键水解的催化活性的金属阳离子。 磷酸酯底物包括核酸如RNA，磷酸酐，磷脂和磷酸烷基酯。

公开(公告)号：US5567687A

公开(公告)日：1996-10-22

申请号：US310501

申请日：1994-09-21

Applicant: Darren Magda ,  Jonathan L. Sessler ,  Brent Iverson ,  Petra L. Jansen ,  Meredith Wright ,  Tarak D. Mody ,  Gregory W. Hemmi

Inventor： Darren Magda ,  Jonathan L. Sessler ,  Brent Iverson ,  Petra L. Jansen ,  Meredith Wright ,  Tarak D. Mody ,  Gregory W. Hemmi

IPC: A61K41/00 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/02 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C12N15/113

CPC classification number: C07D487/22 ,  A61K41/0042 ,  A61K41/0076 ,  A61K47/48069 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/085 ,  A61K49/106 ,  A61K49/126 ,  A61K51/0485 ,  A61L2/0011 ,  B01J31/1658 ,  B01J31/1815 ,  C07H21/00 ,  C12N15/113 ,  B01J2531/025 ,  B01J2531/26 ,  B01J2531/27 ,  B01J2531/33 ,  B01J2531/37 ,  B01J2531/38 ,  B01J31/0201 ,  C12N2310/15 ,  C12N2310/321 ,  C12N2310/3511

Abstract: A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.

Abstract translation: 公开了具有含乙氧基的取代基的泰克萨菲瑞，光动力学治疗中使用泰克萨菲瑞的方法和脱氧核糖核酸的聚合物的切割。 使用Lu（III）泰克萨菲瑞复合物证明体内治疗肿瘤和动脉粥样硬化。 优选的使用方法是脱氧核糖核酸的聚合物的位点特异性切割，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到位点定向分子，优选寡核苷酸的泰克萨菲林。

公开(公告)号：US5559207A

公开(公告)日：1996-09-24

申请号：US227370

申请日：1994-04-14

Applicant: Jonathan L. Sessler ,  Daniel A. Smith ,  Richard A. Miller ,  Kevin L. Ross ,  Meredith Wright ,  William C. Dow ,  Vladimir A. Kr al ,  Brent Iverson ,  Darren Magda

Inventor： Jonathan L. Sessler ,  Daniel A. Smith ,  Richard A. Miller ,  Kevin L. Ross ,  Meredith Wright ,  William C. Dow ,  Vladimir A. Kr al ,  Brent Iverson ,  Darren Magda

IPC: A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07B61/00 ,  C07D487/22 ,  C07F9/06 ,  C07F9/6558 ,  C07F9/6561 ,  C07H21/00 ,  C07K2/00 ,  C07F5/00 ,  C07H3/00 ,  C07K16/00

CPC classification number: A61K47/48069 ,  A61K41/0038 ,  A61K41/0076 ,  A61K49/0021 ,  A61K49/0036 ,  A61K49/085 ,  A61K49/106 ,  A61K49/126 ,  A61K51/0485 ,  A61L2/0011 ,  B01J31/1658 ,  B01J31/1815 ,  C07D487/22 ,  C07H21/00 ,  B01J2531/025 ,  B01J2531/23 ,  B01J2531/26 ,  B01J2531/27 ,  B01J2531/28 ,  B01J2531/38 ,  B01J2531/72 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  B01J2531/96 ,  B01J31/061

Abstract: A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.

Abstract translation: 磷酸酯水解的方法，包括将磷酸酯水溶液与泰克萨菲金属络合物的溶液孵育。 金属是具有催化活性的金属阳离子，用于在水溶液中酯键水解，特别是镧系元素金属阳离子，优选Eu（III）或Dy（III）。 优选的底物是RNA，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到定点分子，优选寡核苷酸的泰克萨菲林。

公开(公告)号：US5607924A

公开(公告)日：1997-03-04

申请号：US469177

申请日：1995-06-06

Applicant: Darren Magda ,  Jonathan L. Sessler ,  Brent L. Iverson ,  Petra I. Sansom ,  Meredith Wright

Inventor： Darren Magda ,  Jonathan L. Sessler ,  Brent L. Iverson ,  Petra I. Sansom ,  Meredith Wright

IPC: C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K38/22 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  A61K51/04 ,  A61L2/00 ,  B01J31/06 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  A61K31/40 ,  A61K31/555

CPC classification number: C12N15/113 ,  A61K41/0038 ,  A61K41/0042 ,  A61K41/0076 ,  A61K47/48023 ,  A61K47/48069 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/06 ,  A61K49/085 ,  A61K49/10 ,  A61K51/0485 ,  A61L2/0011 ,  B01J31/1658 ,  B01J31/1815 ,  C07D487/22 ,  C07H21/00 ,  B01J2531/025 ,  B01J2531/38 ,  B01J31/061 ,  C12N2310/15 ,  C12N2310/321 ,  C12N2310/3511 ,  Y10T436/147777

Abstract: Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.

Abstract translation: 公开了使用光敏泰克萨菲蛋白分解脱氧核糖核酸聚合物的方法。 优选的使用方法是脱氧核糖核酸的聚合物的位点特异性切割，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到位点定向分子，优选寡核苷酸的泰克萨菲林。

公开(公告)号：US06375930B2

公开(公告)日：2002-04-23

申请号：US08975090

申请日：1997-11-20

Applicant: Stuart W. Young ,  Meredith Wright ,  Jonathan L. Sessler ,  Tarak D. Mody ,  Darren Magda

Inventor： Stuart W. Young ,  Meredith Wright ,  Jonathan L. Sessler ,  Tarak D. Mody ,  Darren Magda

IPC: A61B55055

CPC classification number: B82Y5/00 ,  A61K41/0076 ,  A61K47/554 ,  A61K47/6901 ,  A61K47/6911 ,  A61K49/085 ,  A61K49/1896

Abstract: Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic texaphyrin-lipophilic molecule conjugate have utility as a blood pool contrast agent, facilitating the enhancement of normal tissues, magnetic resonance angiography, and marking areas of damaged endothelium by their egress through fenestrations or damaged portions of the blood vascular system. Liposomes or cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate can be photolysed, allowing for a photodynamic therapy effect at the site of lysis. Availability of red blood cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate provides a method for delivering a photodynamic therapeutic agent to a desired site with a high concentration of oxygen. By presenting the agent in this way, it is expected that a patient will experience less toxicity.

Abstract translation: 提供了具有加载到生物囊泡中的泰克萨菲瑞 - 亲脂性分子缀合物的组合物以及使用加载的囊泡进行成像，诊断和治疗的方法。 例如，装载有顺磁性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或红细胞具有作为血液池造影剂的效用，有利于正常组织的增强，磁共振血管造影术，以及通过开窗口或损伤引起的出血损伤的内皮标记区域 部分血管系统。 可以光密化具有感光性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或细胞，从而在裂解部位产生光动力学治疗效果。 载有感光性泰克萨菲瑞 - 亲脂性分子缀合物的红细胞的可获得性提供了一种将光动力治疗剂递送至具有高浓度氧的所需部位的方法。 通过以这种方式呈现代理，预期患者的毒性将较低。

公开(公告)号：US6022959A

公开(公告)日：2000-02-08

申请号：US975522

申请日：1997-11-20

Applicant: Darren Magda ,  Shaun P. Crofts ,  Meredith Wright

Inventor： Darren Magda ,  Shaun P. Crofts ,  Meredith Wright

IPC: C07H21/00 ,  C07H21/02

CPC classification number: C07H21/00

Abstract: Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity for the hydrolysis of ribonucleic acid. Further, conjugates demonstrating catalytic turnover are described, the conjugates being especially effective under conditions where the concentration of RNA target exceeds that of available conjugate.

Abstract translation: 提供了Texaphyrin金属络合物 - 寡核苷酸和寡核苷酸类似物缀合物，其中泰克萨菲瑞与寡核苷酸或寡核苷酸类似物的内部连接键合，该缀合物具有核糖核酸水解的催化活性。 此外，描述了显示催化周转的结合物，缀合物在RNA靶标的浓度超过可用缀合物浓度的条件下特别有效。