Invention Grant
- Patent Title: Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
- Patent Title (中): 适用于异源细胞的移植，分化和增殖的小鼠的方法，通过该方法产生的小鼠和使用小鼠
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Application No.: US10221549Application Date: 2001-10-25
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Publication No.: US07145055B2Publication Date: 2006-12-05
- Inventor: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- Applicant: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- Applicant Address: JP Kanagawa
- Assignee: Central Institute for Experimental Animals
- Current Assignee: Central Institute for Experimental Animals
- Current Assignee Address: JP Kanagawa
- Agency: Heller Ehrman LLP
- Agent Ginger R. Dreger
- Priority: JP2000-367296 20001201
- International Application: PCT/JP01/09401 WO 20011025
- International Announcement: WO02/43477 WO 20020606
- Main IPC: G01N33/00
- IPC: G01N33/00 ; C12N15/01 ; A01K67/02 ; A01K67/027
Abstract:
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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