中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.021 seconds)

    Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof
    1.
    发明申请
    Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof 审中-公开
    椎间盘髓核干细胞/祖细胞，培养方法及其用途

    公开(公告)号：US20130078222A1

    公开(公告)日：2013-03-28

    申请号：US13637470

    申请日：2011-03-29

    Applicant: Daisuke Sakai ,  Joji Mochida ,  Kiyoshi Ando ,  Yoshihiko Nakamura

    Inventor： Daisuke Sakai ,  Joji Mochida ,  Kiyoshi Ando ,  Yoshihiko Nakamura

    IPC: C12N5/071

    CPC classification number: C12N5/0654 ,  A61K35/12 ,  C12N5/0655 ,  C12N5/0668 ,  C12N2501/17 ,  C12N2502/1394 ,  C12N2502/99

    Abstract: Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and is positive for at least one surface marker from among Tie2 and GD2. That is, the intervertebral disk nucleus pulposus stem cell is characterized by being at least Tie2-positive for the surface marker and) possesses a self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. Also provided is an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.

    Abstract translation: 提供可用于治疗椎间盘疾病的椎间盘髓核干细胞或祖细胞。 椎间盘髓核细胞的特征在于从脊椎动物的椎间盘髓核中分离，并且对于Tie2和GD2中的至少一个表面标记是阳性的。 也就是说，椎间盘髓核干细胞的特征在于对于表面标志物至少为Tie2阳性，并且具有能够分化成脂肪细胞，骨细胞，软骨细胞和神经元的自我更新能力以及多能性。 还提供了一种椎间盘髓核祖细胞，其特征在于对于表面标记至少具有Tie2阴性和GD2阳性，并且能够分化成任何脂肪细胞，骨细胞，软骨细胞和神经元。

    Hydrophilic film and process for producing the same
    2.
    发明授权
    Hydrophilic film and process for producing the same 失效
    亲水膜及其制造方法

    公开(公告)号：US06214382B1

    公开(公告)日：2001-04-10

    申请号：US08836049

    申请日：1997-12-23

    Applicant: Tamiyuki Eguchi ,  Kiyoshi Ando ,  Yasuo Shimizu

    Inventor： Tamiyuki Eguchi ,  Kiyoshi Ando ,  Yasuo Shimizu

    IPC: A61K914

    CPC classification number: B01D67/0088

    Abstract: This invention provides a hydrophilic membrane wherein a hydrophilic cellulose derivative of a number average molecular weight of 2000˜8000 is adsorbed irreversibly to a hydrophobic membrane of an aromatic polymer. Since an amount of leaching substances is extremely small, the membrane can be used suitably in such fields as medical applications, electronics, etc. where even a quite small quantity of leaching substances from the membranes is limited especially small.

    Abstract translation: 本发明提供一种亲水性膜，其中数均分子量为2000〜8000的亲水性纤维素衍生物不可逆地吸附在芳香族聚合物的疏水性膜上。由于浸出物质的量极少，因此可以适当地使用 诸如医疗应用，电子等领域，甚至来自膜的相当少量的浸出物质被限制得特别小。

    Linear motion apparatus
    3.
    发明授权
    Linear motion apparatus 失效
    直线运动装置

    公开(公告)号：US5806369A

    公开(公告)日：1998-09-15

    申请号：US730690

    申请日：1996-10-11

    Applicant: Hiroyuki Takenaka ,  Kiyoshi Ando

    Inventor： Hiroyuki Takenaka ,  Kiyoshi Ando

    IPC: B23Q5/34 ,  B23Q1/26 ,  B23Q1/44 ,  F16H19/04 ,  F16H25/02 ,  F16H25/08 ,  F16H31/00 ,  F16H27/00

    CPC classification number: F16H25/02 ,  F16H19/043 ,  F16H25/08 ,  Y10T74/1508

    Abstract: A linear motion apparatus is comprised of: a toothed rail (40); a linearly driving mechanism section (50) having a plurality of swinging plates (53), crankshafts (54, 55), and a casing (51); and guiding means for guiding the casing (51) relatively movably with respect to the toothed rail (40). The casing (51) includes: a pair of side portions (61, 62) which are guided by the guiding means on both sides, in a tooth width direction, of the rail (40); a pair of end plate portions (63, 64) which are located on opposite sides, as viewed in a longitudinal direction of the rail (40), of the swinging plates (53) and connect opposite end portions of the pair of side plate portions (61, 62); and a coupling member (521) which is located between the plurality of crankshafts (54, 55) as viewed in the longitudinal direction of the rail and couple intermediate portions of the pair of side plate portions (61, 62). The coupling member (521) is preferably passed through the swinging plates (53). The linear motion apparatus is compact and low-cost, and capable of maintaining a stable state of meshing between swinging plates and a toothed rail even if a compact casing is adopted.

    Abstract translation: 线性运动装置包括：齿条（40）; 具有多个摆动板（53），曲轴（54,55）和壳体（51）的直线驱动机构部（50）。 以及用于相对于所述齿条（40）相对可移动地引导所述壳体（51）的引导装置。 所述壳体（51）包括：一对侧部（61,62），其在所述导轨（40）的齿宽方向的两侧被所述引导装置引导; 一对端板部分（63,64），其位于相对侧的轨道（40）的纵向方向上的摆动板（53）中，并且连接该对侧板部分的相对端部 （61,62）; 以及耦合构件（521），其位于所述多个曲轴（54,55）之间，并且在所述一对侧板部（61,62）的中心部分相连接。 联接构件（521）优选地通过摆动板（53）。 直线运动装置紧凑且成本低，并且即使采用紧凑的壳体，也能够保持摆动板和齿条之间的啮合的稳定状态。

    Mutual exclusion control apparatus for mutual exclusion control based on locking and unlocking requests
    4.
    发明授权
    Mutual exclusion control apparatus for mutual exclusion control based on locking and unlocking requests 失效
    基于锁定和解锁请求的互斥控制互斥控制装置

    公开(公告)号：US5623671A

    公开(公告)日：1997-04-22

    申请号：US403107

    申请日：1995-03-13

    Applicant: Kiyoshi Ando ,  Toyotugu Kasahara ,  Jyunichi Kawakubo

    Inventor： Kiyoshi Ando ,  Toyotugu Kasahara ,  Jyunichi Kawakubo

    IPC: G06F15/16 ,  G06F9/46 ,  G06F9/52 ,  G06F12/14 ,  G06F15/177 ,  G06F13/00

    CPC classification number: G06F9/52 ,  G06F12/1433 ,  G06F9/3004 ,  G06F9/30087

    Abstract: A mutual exclusion control is performed with dynamically, allocated lock variables. A lock request circuit issues a lock acquisition request or an unlock request. A lock identifying information holding circuit holds an identifying information related to a currently valid lock. A lock identifying information comparing circuit judges whether or not a lock identifying information from the lock request circuit is included in the lock identifying information holding circuit. A lock identifying information updating circuit updates the lock identifying information holding circuit on the basis of the request from the lock request circuit.

    Abstract translation: 使用动态分配的锁定变量执行互斥控制。 锁定请求电路发出锁定获取请求或解锁请求。 锁识别信息保持电路保存与当前有效锁相关的识别信息。 锁定识别信息比较电路判断锁定识别信息保持电路中是否包含来自锁定请求电路的锁定识别信息。 锁识别信息更新电路根据来自锁定请求电路的请求更新锁定识别信息保持电路。

    NUCLEIC ACID-CONTAINING COMPLEX
    5.
    发明申请
    NUCLEIC ACID-CONTAINING COMPLEX 审中-公开
    含有核酸的复合物

    公开(公告)号：US20090203768A1

    公开(公告)日：2009-08-13

    申请号：US11740200

    申请日：2007-04-25

    Applicant: Hidezo Mori ,  Yasuhiko Tabata ,  Kiyoshi Ando ,  Etsuro Tanaka ,  Harukazu Iseki ,  Hiromi Sakamoto ,  Naoto Fukuyama ,  Hirofumi Kasahara

    Inventor： Hidezo Mori ,  Yasuhiko Tabata ,  Kiyoshi Ando ,  Etsuro Tanaka ,  Harukazu Iseki ,  Hiromi Sakamoto ,  Naoto Fukuyama ,  Hirofumi Kasahara

    IPC: A61K31/7088 ,  A61P35/00 ,  A61K9/14

    CPC classification number: A61K47/643

    Abstract: A nucleic acid-containing complex, containing a nucleic acid and a biodegradable polymer, especially a positively-charged water-insoluble biodegradable polymer, is disclosed. The complex has excellent properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site in need of a treatment. Since the complex can be taken up to phagocytes such as macrophages and delivered specifically to the target site, the function of the nucleic acid can be exhibited in a target site specific manner, and thus more specific gene therapy can be achieved. The complex has no adverse effects, such as occurrence of recombinants or toxicity which could be caused by using a virus vector such as adenovirus, or liposome. Thus, the complex is particularly preferable for the field of gene therapy. Furthermore, the complex enhances the biological effect of the nucleic acid introduced into the cells, allowing a gene therapy with a lower dose of nucleic acids.

    Abstract translation: 公开了含有核酸和可生物降解的聚合物，特别是带正电的水不溶性可生物降解聚合物的含核酸复合物。 该复合物具有将期望的核酸，特别是DNA持续释放到需要治疗的部位的优异性质。 由于复合物可以被吸收到诸如巨噬细胞的吞噬细胞并且特异性递送到靶位点，因此可以以靶位点特异性方式显示核酸的功能，从而可以实现更具体的基因治疗。 该复合物没有不利影响，例如可能由使用病毒载体如腺病毒或脂质体引起的重组体或毒性的发生。 因此，该复合物对于基因治疗领域是特别优选的。 此外，复合物增强引入细胞的核酸的生物学效应，允许用较低剂量的核酸进行基因治疗。

    VACUUM SYSTEM AND METHOD FOR OPERATING THE SAME
    6.
    发明申请
    VACUUM SYSTEM AND METHOD FOR OPERATING THE SAME 审中-公开
    真空系统及其操作方法

    公开(公告)号：US20090112370A1

    公开(公告)日：2009-04-30

    申请号：US11996326

    申请日：2006-07-14

    Applicant: Hiroyuki Tanaka ,  Kiyoshi Ando

    Inventor： Hiroyuki Tanaka ,  Kiyoshi Ando

    IPC: G05D7/06

    CPC classification number: F04D19/046 ,  F04B37/14 ,  F04D27/00

    Abstract: The present invention provides a vacuum system including a vacuum pump capable of operating at a rotation rate controlled appropriately when a predetermined process is performed in a vacuum chamber, which contributes to energy conservation. The vacuum system serves as a semiconductor manufacturing system comprising a vacuum pump controller which has a gas flow mode and an auto-tuning mode for determining a rotation rate of a vacuum pump unit to set the rotation rate to a target value lower by a predetermined value than the full operation rate of gas flow rate control means under the condition that pressure within the process chamber is vacuum pressure necessary for the gas flow mode. The vacuum pump controller has means for reducing the rotation rate of the vacuum pump unit from a rated rotation rate in the auto-tuning mode under the condition that pressure within the process chamber is vacuum necessary for the gas flow mode, to determine whether or not the operation rate of an APC valve reaches a target value, and means for storing, as the rotation rate necessary for the gas flow mode, the rotation rate of the vacuum pump unit, which is obtained when it is determined that the operation rate of the APC valve reaches the target value.

    Abstract translation: 本发明提供了一种真空系统，其包括真空泵，该真空泵能够在真空室中进行预定的处理时适当地控制旋转速度，这有助于节能。 真空系统用作半导体制造系统，其包括具有气体流动模式和自动调谐模式的真空泵控制器，该自动调谐模式用于确定真空泵单元的转速以将转速设定为目标值低预定值 比在处理室内的压力为气体流动模式所需的真空压力的条件下的气体流量控制装置的全部操作速率。 真空泵控制器具有用于在自动调谐模式下在额定转速下降低真空泵单元的旋转速度的装置，在处理室内的压力为气体流动模式需要真空的条件下，确定是否 APC阀的运转速度达到目标值，以及存储作为气体流动模式所需的旋转速度的真空泵单元的旋转速度的装置，当确定真空泵单元的运转速度时， APC阀达到目标值。

    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
    7.
    发明授权
    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor 失效
    判断白血病，白血病前或白血病恶性血液病的诊断方法

    公开(公告)号：US07479371B2

    公开(公告)日：2009-01-20

    申请号：US10510627

    申请日：2003-04-09

    Applicant: Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    Inventor： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    IPC: G01N33/53 ,  C07K16/00

    CPC classification number: C07K16/22 ,  G01N33/57426 ,  G01N2333/475

    Abstract: The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

    Abstract translation: 本发明涉及白血病，白血病前或白血病恶性血液病诊断方法，白血病与白血病前白血病恶性血液疾病的鉴别方法，再生障碍性贫血与骨髓增生异常综合征的鉴别方法，延迟诊断方法 造血干细胞移植后造血干细胞的移植，以及诊断移植物抗宿主病的方法，每种方法包括量化干细胞生长因子（SCGF）。 本发明还可以提供用于诊断白血病，白血病前或白血病恶性血液病的药剂和用于诊断造血干细胞移植后的造血干细胞的延迟植入或用于诊断移植物与宿主的试剂的试剂 疾病（GVHD），各自含有与干细胞生长因子（SCGF）反应的抗体作为活性成分。

Patent Agency Ranking