Invention Grant
US07390661B2 Artificial bidirectional promoter for activation of gene expression
有权
用于激活基因表达的人工双向启动子
- Patent Title: Artificial bidirectional promoter for activation of gene expression
- Patent Title (中): 用于激活基因表达的人工双向启动子
-
Application No.: US11542590Application Date: 2006-10-03
-
Publication No.: US07390661B2Publication Date: 2008-06-24
- Inventor: Rakesh Tuli , Sawant Samir Vishwanath , Chandra Prakash Chaturvedi , Kanti Kiran , Rajesh Mehrotra
- Applicant: Rakesh Tuli , Sawant Samir Vishwanath , Chandra Prakash Chaturvedi , Kanti Kiran , Rajesh Mehrotra
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific and Industrial Research
- Current Assignee: Council of Scientific and Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Ladas & Parry LLP
- Main IPC: C12N5/14
- IPC: C12N5/14 ; C12N5/04 ; C12N15/00 ; C12N15/09 ; C12N15/11 ; C12P21/06 ; A01H1/00

Abstract:
A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence elements, strategically arranged to give a ‘Transcription Activating Module’ that achieves high level expression from a ‘Transcription Initiation Module’. The latter functions like a minimal promoter. The former activates transcription simultaneously in both the directions from the latter and also responds to several transcription inducing, external stimuli in both the directions. Since it is an artificially designed bidirectional transcription module, it has no equivalent DNA sequence in plant genome. This reduces the chances of the genes from being silenced by homology based mechanisms. A bidirectional promoter module as this, can therefore be used to develop efficient vectors for genetic engineering in plants.
Public/Granted literature
- US20070028323A1 Artificial bidirectional promoter for activation of gene expression Public/Granted day:2007-02-01
Information query