Invention Grant
US07671190B2 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof
有权
编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
- Patent Title: Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof
- Patent Title (中): 编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
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Application No.: US11654485Application Date: 2007-01-16
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Publication No.: US07671190B2Publication Date: 2010-03-02
- Inventor: Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
- Applicant: Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
- Applicant Address: US NJ Princeton
- Assignee: Kosan Biosciences Incorporation
- Current Assignee: Kosan Biosciences Incorporation
- Current Assignee Address: US NJ Princeton
- Agent Stephen C. D'Amico
- Main IPC: C12N15/53
- IPC: C12N15/53 ; C12N15/74 ; C12N15/76 ; C12N15/31 ; C12N9/06
Abstract:
The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
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