A system for protecting data during high-speed bidirectional communication between a master device and a slave device. The master device may control data transfer between the master device and the slave device. In addition, the master device may perform a read request to the slave device for a first data block associated with a first address and a second data block associated with a second address. In response, the slave device may send to the master device a portion of the first data block in a first burst and a portion of the second data block in a second burst via a plurality of bidirectional data paths. The slave device may further generate and send to the master device via one or more unidirectional data paths a cyclic redundancy code (CRC) based upon the first data block and the second data block.