Invention Grant
- Patent Title: Method of constructing spinal injury model monkey and utilization thereof
- Patent Title (中): 构建脊髓损伤模型猴的方法及其应用
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Application No.: US10496993Application Date: 2002-11-26
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Publication No.: US07753054B2Publication Date: 2010-07-13
- Inventor: Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
- Applicant: Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
- Applicant Address: JP Kawaguchi-shi JP Tokyo
- Assignee: Japan Science and Technology Agency,Keio University
- Current Assignee: Japan Science and Technology Agency,Keio University
- Current Assignee Address: JP Kawaguchi-shi JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2001-364563 20011129
- International Application: PCT/JP02/12308 WO 20021126
- International Announcement: WO03/045137 WO 20030605
- Main IPC: A61B19/00
- IPC: A61B19/00

Abstract:
A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
Public/Granted literature
- US20050186545A1 Method of constructing spinal injury model monkey and utilization thereof Public/Granted day:2005-08-25
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