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Invention Grant
US07867741B2 Polypeptides having an activity in the MTBE degradation path and uses thereof 有权
在MTBE降解途径中具有活性的多肽及其用途

Polypeptides having an activity in the MTBE degradation path and uses thereof
Abstract:
The invention concerns an isolated or purified polypeptide having an activity in the MTBE degradation path, and/or at least one of the catabolic intermediates of MTBE, preferably selected from the group consisting of tert-butyl alcohol (TBA), 2-methyl 1,2-propanediol (2-M1, 2-PD), hydroxyisobutyraldehyde, hydroxyiso-butyric acid (HIBA), said polypeptide being selected from the group consisting of: a) a polypeptide comprising a sequence of amino acids selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 or SEQ ID NO:10; b) a polypeptide comprising a sequence of amino acids having at least 70% identity, preferably 75%, 80%, 90%, 95%, 98% or 99% with the sequence of amino acids of a polypeptide as defined in a); a polypeptide as defined in a) or b) whereof the sequence of amino acids comprises a substitution, deletion, insertion, addition or mutation of one or several amino acids over its entire length.
Abstract(Chinese):

本发明涉及在MTBE降解途径中具有活性的分离或纯化的多肽，和/或MTBE的分解代谢中间体中的至少一种，优选选自叔丁醇（TBA），2-甲基1， 2-丙二醇（2-M1，2-PD），羟基异丁醛，羟基异丁酸（HIBA），所述多肽选自：a）包含选自下组的氨基酸序列的多肽 SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8或SEQ ID NO：10; b）包含与a）中所定义的多肽的氨基酸序列具有至少70％同一性，优选75％，80％，90％，95％，98％或99％的氨基酸序列的多肽; a）或b）中定义的多肽，其中氨基酸序列包括其整个长度上一个或几个氨基酸的取代，缺失，插入，添加或突变。

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