A nebulization apparatus with a packaging and fixing structure includes a piezoelectric driving device, an adhesive agent, a nebulization plate, a packaging layer and a fixing base. A ditch at the piezoelectric driving device is provided for filling an adhesive agent and installing the nebulization plate that is fixed to the driving device by the adhesive agent. The packaging layer covers the piezoelectric driving device. The fixing base fixes the piezoelectric driving device. Preferably, the packaging layer is made of a polymer material for insulating moisture and preventing short circuits of the piezoelectric driving device. The ditch and the adhesive agent enhance the attaching strength of the piezoelectric driving device and the nebulization plate to extend the life of the nebulization apparatus, and the adhesive agent can electrically insulate the nebulization plate and the piezoelectric driving device, such that the nebulization plate will have no electrochemical action with the liquid.