Invention Grant
- Patent Title: Porous biomaterials surface activation method
- Patent Title (中): 多孔生物材料表面活化法
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Application No.: US12487101Application Date: 2009-06-18
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Publication No.: US08216630B2Publication Date: 2012-07-10
- Inventor: Hélène Autefage , Sophie Cazalbou , Christèle Combes , Christian Rey
- Applicant: Hélène Autefage , Sophie Cazalbou , Christèle Combes , Christian Rey
- Applicant Address: FR Toulouse Cedex FR Vic-En-Bigorre Cedex
- Assignee: Institut National Polytechnique de Toulouse,TEKNIMED
- Current Assignee: Institut National Polytechnique de Toulouse,TEKNIMED
- Current Assignee Address: FR Toulouse Cedex FR Vic-En-Bigorre Cedex
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Main IPC: B05D3/02
- IPC: B05D3/02 ; A61L27/32 ; A61F2/28 ; A61K33/42

Abstract:
The present invention relates to a porous biomaterials surface activation method by coating with a layer of apatitic nanocrystals in order to increase their surface reactivity. The method according to the invention is characterized by the following steps: a) preparing a nanocrystalline apatitic calcium phosphate analogous to bone mineral by mixing a calcium salt solution with a phosphate salt solution in a Ca/P ratio ranging between 1.3 and 2 at a temperature ranging between 0 and 60 ° C., b) slurrying the mixture obtained in step a) in an aqueous solution so as to obtain a fluid, homogeneous paste containing 80 to 98% of water, c) bringing a porous biomaterial into contact with the suspension obtained in step b), d) drying the porous biomaterial at a temperature below 100 ° C.
Public/Granted literature
- US20100323094A1 POROUS BIOMATERIALS SURFACE ACTIVATION METHOD Public/Granted day:2010-12-23
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