Invention Grant
- Patent Title: Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations
- Patent Title (中): 通过腺病毒和腺相关病毒介导的给药顺序递送免疫原性分子
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Application No.: US11587543Application Date: 2005-04-27
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Publication No.: US08394386B2Publication Date: 2013-03-12
- Inventor: James M. Wilson
- Applicant: James M. Wilson
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Howson & Howson LLP
- International Application: PCT/US2005/014556 WO 20050427
- International Announcement: WO2006/078279 WO 20060727
- Main IPC: A61K39/23
- IPC: A61K39/23 ; A61K39/116 ; C12Q1/70
Abstract:
An immunogenic regimen is provided. The regimen involves sequential administration of a recombinant adenoviral vector and a recombinant adeno-associated viral vector, each of which delivers a heterologous expression cassette encoding the same immunogenic product, or a cross-reactive immunogenic product. Also provided are products containing the vectors for use in the regimen of the invention.
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