Invention Grant
US08415291B2 Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
有权
抗TNFα纤连蛋白III型结构域的支架组合物，方法和用途
- Patent Title: Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
- Patent Title (中): 抗TNFα纤连蛋白III型结构域的支架组合物，方法和用途
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Application No.: US12606396Application Date: 2009-10-27
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Publication No.: US08415291B2Publication Date: 2013-04-09
- Inventor: Steven Jacobs , Karyn O'Neil
- Applicant: Steven Jacobs , Karyn O'Neil
- Applicant Address: US PA Horsham
- Assignee: Centocor Ortho Biotech Inc.
- Current Assignee: Centocor Ortho Biotech Inc.
- Current Assignee Address: US PA Horsham
- Agent Eric Dichter
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K1/00 ; C07K16/00 ; C12P21/08
Abstract:
A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Public/Granted literature
- US20100144601A1 Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses Public/Granted day:2010-06-10
Information query
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