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    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    2.
    发明申请
    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权
    纤连蛋白III型域支架组合物，方法和用途

    公开(公告)号：US20130096019A1

    公开(公告)日：2013-04-18

    申请号：US13595484

    申请日：2012-08-27

    Applicant: Steven Jacobs ,  Karyn O'Neil

    Inventor： Steven Jacobs ,  Karyn O'Neil

    IPC: C07K14/78

    CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

    Methods of Predicting Antibody Solubility
    3.
    发明申请
    Methods of Predicting Antibody Solubility 审中-公开
    预测抗体溶解度的方法

    公开(公告)号：US20110189790A1

    公开(公告)日：2011-08-04

    申请号：US12863489

    申请日：2009-01-20

    Applicant: Karyn O'Neil ,  Steven Jacobs ,  Shong-Juin Wu ,  Deldra Bethea ,  Ylqing Feng

    Inventor： Karyn O'Neil ,  Steven Jacobs ,  Shong-Juin Wu ,  Deldra Bethea ,  Ylqing Feng

    IPC: G01N30/02

    CPC classification number: G01N33/6854 ,  B01D15/3809

    Abstract: The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.

    Abstract translation: 本发明提供了用于测试和评估与溶解度相关的生物物理性质的治疗性抗体候选物和抗体在水溶液中聚集的易感性的方法。 该方法可用于在可以以高浓度配制的候选物之间选择抗体文库或变体。

    MANUALLY DRIVEN DETERMINATION OF A REGION OF INTEREST (ROI) OR A PATH OF INTEREST (POI) FOR A ROBOTIC DEVICE
    4.
    发明申请
    MANUALLY DRIVEN DETERMINATION OF A REGION OF INTEREST (ROI) OR A PATH OF INTEREST (POI) FOR A ROBOTIC DEVICE 审中-公开
    手动驱动一个兴趣区域（ROI）或一个机器人的兴趣之路（POI）的确定

    公开(公告)号：US20100076599A1

    公开(公告)日：2010-03-25

    申请号：US12234633

    申请日：2008-09-20

    Applicant: Steven Jacobs ,  Kipp Knutson ,  David Wood

    Inventor： Steven Jacobs ,  Kipp Knutson ,  David Wood

    IPC: B25J19/02 ,  B25J9/22

    CPC classification number: G05D1/0272 ,  G05D1/0221 ,  G05D1/0255 ,  G05D1/028

    Abstract: A robotic device is manually driven along a perimeter of a Region Of Interest (ROI) or along a Path Of Interest (POI) for future autonomous operation. An Initial Point (IP) is established by identifying a unique machine recognizable feature, for example, a Radio Frequency Identification (RFID) tag located at the IP. The robotic device is then manually driven along the perimeter or along the path and sensors carried by the robotic device collects data to characterize the ROI or POI. The sensors may include sonar, vision systems, laser, or radar devices for measuring relative positions of a wall, stairs, or obstacles. Wheel odometry may be used to track distances traveled and data fusion exercised to combine the odometry data with the sonar and/or laser measurements to model the ROI or POI. Characterization is performed by collecting points along a wall, fitting a line to the points, and finding the intersections of consecutive lines.

    Abstract translation: 机器人装置沿着感兴趣区域（ROI）或沿着感兴趣路径（POI）的周边手动驱动以用于将来的自主操作。 通过识别唯一的机器可识别特征（例如位于IP处的射频识别（RFID））标签来建立初始点（IP）。 然后机器人装置沿着周边或沿着路径手动驱动，并且机器人装置携带的传感器收集数据以表征ROI或POI。 传感器可以包括用于测量墙壁，楼梯或障碍物的相对位置的声纳，视觉系统，激光或雷达装置。 轨迹测距可用于跟踪所行驶的距离和数据融合，以将测距数据与声纳和/或激光测量结合以对ROI或POI进行建模。 通过沿着墙壁收集点，将线拟合到点上并找到连续线的交点来进行表征。

    HINGE ASSEMBLY
    7.
    发明申请
    HINGE ASSEMBLY 有权
    铰链装配

    公开(公告)号：US20150337579A1

    公开(公告)日：2015-11-26

    申请号：US14650880

    申请日：2012-12-17

    Applicant: Steven JACOBS ,  HEWLETT PACKARD DEVELOPMENTCOMPANY L.P.

    Inventor： Steven Jacobs

    IPC: E05D11/08 ,  E05D3/02 ,  G06F1/16 ,  E05D11/00

    CPC classification number: E05D11/082 ,  E05D3/02 ,  E05D11/0081 ,  E05D11/06 ,  E05D11/084 ,  E05Y2900/606 ,  G06F1/1616 ,  G06F1/1681 ,  Y10T16/522 ,  Y10T16/538 ,  Y10T16/53885 ,  Y10T16/54034 ,  Y10T16/54035 ,  Y10T16/54038

    Abstract: A hinge assembly is disclosed herein. An example includes a first knuckle including a first wall that defines a first cavity and second knuckle including a second wall that defines a second cavity. The example also includes a friction element disposed in both the first cavity defined by the first wall of the first knuckle and the second cavity defined by the second wall of the second knuckle to both rotatably and resistively couple the first knuckle to the second knuckle by application of a force directed toward the first wall and the second wall, the friction element including a third wall that defines a third cavity. Modifications and additions to, as well as other examples of, the hinge assembly are also disclosed herein.

    Abstract translation: 本文公开了铰链组件。 一个例子包括第一转向节，其包括限定第一腔的第一壁和包括限定第二腔的第二壁的第二转向节。 该实施例还包括摩擦元件，其设置在由第一转向节的第一壁限定的第一空腔和由第二转向节的第二壁限定的第二腔中，并且通过施加可旋转地和电阻地将第一转向节连接到第二转向节 指向第一壁和第二壁的力，摩擦元件包括限定第三腔的第三壁。 本文还公开了铰链组件的修改和添加以及其他示例。

    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    10.
    发明申请
    Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权
    纤连蛋白III型域支架组合物，方法和用途

    公开(公告)号：US20100216708A1

    公开(公告)日：2010-08-26

    申请号：US12606382

    申请日：2009-10-27

    Applicant: Steven Jacobs ,  Karyn O'Neil

    Inventor： Steven Jacobs ,  Karyn O'Neil

    IPC: A61K38/16 ,  C07K14/00 ,  C40B50/00 ,  C40B40/10 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10

    CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

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